ATF1

Across TCGA pan-cancer cohorts, ATF1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ATF1 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ATF1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SKCM, LUAD, and ACC are the cancer types where ATF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	III,IV	0.043	0.597	<.001	27	view →
LUAD	DFS	Median	All	0.293	0.792	<.001	18	view →
ACC	OS	Median	All	0.273	0.802	.017	15	view →
UCEC	DFS	Median	All	1.000	0.829	.018	10	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ATF1–SKCM (DFS)

Open the SKCM breakdown →