ATF1

Across TCGA patient cohorts, ATF1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATF1-associated genes across cancer lineages are Rad50, EGFR_pY1068, and ACC_pS79. Each is linked with ATF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATF1-to-partner and partner-to-ATF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by ATF1-low versus ATF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF1→partner) and Y-score (partner→ATF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.219	-1.807	.028	.027	3	2
UCEC	EGFR_pY1068 →	-0.218	-2.321	.035	.006	3	1
UCEC	ACC_pS79 →	+0.366	+2.459	.010	.018	3	1
UCEC	ACC1 →	+0.302	+2.183	.044	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.163	-1.794	.019	.027	3	1
UCEC	JNK2 →	+0.285	+2.321	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Rad50 by ATF1 expression — UCEC

Explore this box plot interactively →