ATF1

Across TCGA cell cohorts, ATF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,871 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATF1-associated GO terms across cancer lineages are Regulation of DNA damage checkpoint, Establishment of mitotic sister chromatid cohesion, and Double-strand break repair via nonhomologous end joining. Each is linked with ATF1 in more than 11 cancer types. Because this analysis shows association rather than direction, both ATF1-to-partner and partner-to-ATF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA damage checkpoint grouped by ATF1-low versus ATF1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATF1→partner) and Y-score (partner→ATF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of DNA damage checkpoint →	+0.111	+0.632	<.001	<.001	3	12
BLOOD_Leukemia	Establishment of mitotic sister chromatid cohesion →	+0.110	+0.618	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.047	+0.535	<.001	<.001	3	12
BLOOD_Myeloma	Regulation of sister chromatid cohesion →	+0.095	+0.730	<.001	.001	3	11
CNS	Mitotic sister chromatid segregation →	+0.089	+0.530	<.001	<.001	3	11
BLOOD_Leukemia	Regulation of cytokinesis →	+0.073	+0.645	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,871 associations by consensus.

Regulation of DNA damage checkpoint by ATF1 expression — OVARY

Explore this box plot interactively →