ATE1

Across TCGA patient cohorts, ATE1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATE1-associated genes across cancer lineages are SETD2, VHL, and MEK1. Each is linked with ATE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATE1-to-partner and partner-to-ATE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SETD2 grouped by ATE1-low versus ATE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATE1→partner) and Y-score (partner→ATE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SETD2 →	-0.221	-3.000	.036	.036	3	1
UCEC	VHL →	-0.757	-2.321	.021	.034	3	1
UCEC	MEK1 →	+0.439	+2.459	.012	.020	2	1
UCEC	p62 Lck ligand →	+0.443	+3.331	.004	.005	2	1
UCEC	Tuberin →	+0.361	+3.584	.005	.002	1	1
UCEC	Caspase-8 →	-0.332	-2.459	.006	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SETD2 by ATE1 expression — UCEC

Explore this box plot interactively →