ATE1

Across TCGA cell cohorts, ATE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,627 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATE1-associated GO terms across cancer lineages are Ubiquitin-dependent protein catabolic process via the N-end rule pathway, Viral translational termination-reinitiation, and Regulation of sister chromatid cohesion. Each is linked with ATE1 in more than 14 cancer types. Because this analysis shows association rather than direction, both ATE1-to-partner and partner-to-ATE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ubiquitin-dependent protein catabolic process via the N-end rule pathway grouped by ATE1-low versus ATE1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATE1→partner) and Y-score (partner→ATE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Ubiquitin-dependent protein catabolic process via the N-end rule pathway →	+0.088	+0.925	<.001	.001	3	15
LARGE_INTESTINE	Viral translational termination-reinitiation →	+0.103	+0.973	<.001	<.001	3	15
BLOOD_Myeloma	Regulation of sister chromatid cohesion →	+0.120	+1.256	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair →	+0.062	+0.730	<.001	<.001	3	12
BREAST	Double-strand break repair via nonhomologous end joining →	+0.053	+0.780	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	DNA biosynthetic process →	+0.067	+0.760	.003	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,627 associations by consensus.

Ubiquitin-dependent protein catabolic process via the N-end rule pathway by ATE1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →