ATE1

Across TCGA cell cohorts, ATE1 mutation is significantly associated with the drug of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATE1-associated genes across cancer lineages are Methotrexate, GSK1904529A, and CDK9_5576. Each is linked with ATE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATE1-to-partner and partner-to-ATE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Methotrexate grouped by ATE1-low versus ATE1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATE1→partner) and Y-score (partner→ATE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Methotrexate →	+1.236	+3.000	<.001	.014	3	1
LARGE_INTESTINE	GSK1904529A →	+0.352	+2.678	.019	.037	3	1
LARGE_INTESTINE	CDK9_5576 →	+0.562	+3.064	.016	.009	3	1
LARGE_INTESTINE	Savolitinib →	+0.336	+2.678	.039	.037	3	1
LARGE_INTESTINE	Mirin →	+0.450	+3.061	.007	.010	2	1
LARGE_INTESTINE	PAK_5339 →	+0.276	+2.678	.041	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Methotrexate by ATE1 expression — LARGE_INTESTINE

Explore this box plot interactively →