ATAT1

Across TCGA patient cohorts, ATAT1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATAT1-associated genes across cancer lineages are HER3_pY1289, ATM, and c-Met_pY1235. Each is linked with ATAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATAT1-to-partner and partner-to-ATAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by ATAT1-low versus ATAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATAT1→partner) and Y-score (partner→ATAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.066	+1.952	.032	.002	3	2
UCEC	ATM →	-0.493	-1.925	.002	.005	3	2
UCEC	c-Met_pY1235 →	+0.080	+2.009	.002	.005	3	2
UCEC	EGFR_pY1068 →	-0.286	-2.321	.001	.001	3	1
UCEC	ERK2 →	+0.154	+1.584	.026	.019	3	1
UCEC	FASN →	+0.396	+1.925	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

HER3_pY1289 by ATAT1 expression — UCEC

Explore this box plot interactively →