ATAD5

Across TCGA patient cohorts, ATAD5 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATAD5-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and ASNS. Each is linked with ATAD5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATAD5-to-partner and partner-to-ATAD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ATAD5-low versus ATAD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATAD5→partner) and Y-score (partner→ATAD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.391	+1.242	.017	.020	3	3
COAD	EGFR_pY1068 →	-0.312	-3.000	.035	.034	3	2
COAD	ASNS →	+0.521	+2.330	.003	.020	3	2
COAD	C-Raf →	+0.140	+2.330	.034	.020	3	2
UCEC	ERK2 →	+0.130	+1.064	.015	.043	3	2
UCEC	FoxM1 →	+0.149	+1.321	.038	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Caspase-7-cleavedD198 by ATAD5 expression — UCEC

Explore this box plot interactively →