ATAD2

Across TCGA patient cohorts, ATAD2 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATAD2-associated genes across cancer lineages are mTOR_pS2448, MIG-6, and C-Raf. Each is linked with ATAD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATAD2-to-partner and partner-to-ATAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ATAD2-low versus ATAD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATAD2→partner) and Y-score (partner→ATAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.089	-1.349	.021	.031	3	4
CESC	MIG-6 →	+0.125	+2.842	.028	.032	2	4
UCEC	C-Raf →	+0.091	+1.353	.014	.013	3	3
UCEC	Cyclin-B1 →	+0.495	+1.938	<.001	.001	3	3
UCEC	Caspase-8 →	-0.161	-1.973	.013	<.001	3	2
UCEC	eEF2 →	+0.207	+2.169	.025	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

mTOR_pS2448 by ATAD2 expression — UCEC

Explore this box plot interactively →