ATAD2

Across TCGA cell cohorts, ATAD2 mutation is significantly associated with the RNA expression of many other genes, with 243 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATAD2-associated genes across cancer lineages are SCGB3A2, HECA, and MT1E. Each is linked with ATAD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATAD2-to-partner and partner-to-ATAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB3A2 grouped by ATAD2-low versus ATAD2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATAD2→partner) and Y-score (partner→ATAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SCGB3A2 →	+0.116	+4.362	<.001	.001	3	2
LUNG_NSCLC_LUAD	HECA →	+0.695	+3.169	<.001	.008	3	2
LUNG_NSCLC_LUAD	MT1E →	+3.823	+3.358	<.001	.003	3	2
LUNG_NSCLC_LUAD	FOXD4L1 →	+0.217	+3.473	<.001	.002	3	2
LARGE_INTESTINE	GRK4 →	+0.702	+3.212	<.001	.006	3	2
LARGE_INTESTINE	NARS1 →	+0.799	+3.212	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 243 associations by consensus.

SCGB3A2 by ATAD2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →