ATAD1

Across TCGA patient cohorts, ATAD1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATAD1-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and Acetyl-a-Tubulin-Lys40. Each is linked with ATAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATAD1-to-partner and partner-to-ATAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ATAD1-low versus ATAD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATAD1→partner) and Y-score (partner→ATAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.295	-2.999	.009	.035	3	1
UCEC	A-Raf_pS299 →	-0.158	-2.000	.003	.032	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.728	+2.179	.001	.034	3	1
UCEC	MEK1 →	+0.368	+2.321	.025	.034	3	1
UCEC	MIG-6 →	+0.090	+2.013	.045	.018	3	1
UCEC	p62 Lck ligand →	+0.300	+2.817	.040	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR_pY1068 by ATAD1 expression — UCEC

Explore this box plot interactively →