ASXL1

Across TCGA patient cohorts, ASXL1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,424 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ASXL1-associated proteins across cancer lineages are ADNP, RPRD1B, and SMC1A. Each is linked with ASXL1 in more than 7 cancer types. Because this analysis shows association rather than direction, both ASXL1-to-partner and partner-to-ASXL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ASXL1 versus ADNP in GBM, with a Pearson correlation of 0.65.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ASXL1→partner) and Y-score (partner→ASXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADNP →	+0.413	+0.379	<.001	<.001	3	8
GBM	RPRD1B →	+0.366	+0.442	<.001	<.001	3	8
BRCA	SMC1A →	+0.300	+0.505	<.001	<.001	3	8
GBM	SMC3 →	+0.293	+0.251	<.001	<.001	3	8
GBM	RAD21 →	+0.291	+0.269	<.001	<.001	3	7
LSCC	RALY →	+0.402	+0.537	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,424 associations by consensus.

ASXL1 vs ADNP — GBM

Explore this scatter interactively →