ASXL1

Across TCGA patient cohorts, ASXL1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASXL1-associated genes across cancer lineages are Caspase-7-cleavedD198, c-Kit, and Cyclin-B1. Each is linked with ASXL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASXL1-to-partner and partner-to-ASXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ASXL1-low versus ASXL1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASXL1→partner) and Y-score (partner→ASXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.276	+3.016	<.001	.018	3	3
SKCM	c-Kit →	-0.773	-2.321	.017	.035	3	2
SKCM	Cyclin-B1 →	+0.471	+2.820	.020	.035	3	2
UCEC	MEK1 →	+0.288	+1.736	.006	.006	3	2
UCEC	Notch1 →	+0.150	+2.013	<.001	.001	3	2
UCEC	p27_pT198 →	+0.065	+1.906	.033	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by ASXL1 expression — COAD

Explore this box plot interactively →