ASXL1

Across TCGA cell cohorts, ASXL1 mutation is significantly associated with the RNA expression of many other genes, with 454 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ASXL1-associated genes across cancer lineages are PROKR2, GRK7, and UGT3A1. Each is linked with ASXL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASXL1-to-partner and partner-to-ASXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROKR2 grouped by ASXL1-low versus ASXL1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASXL1→partner) and Y-score (partner→ASXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PROKR2 →	+0.046	+2.847	.003	.004	3	3
LUNG_NSCLC_LUAD	GRK7 →	+0.060	+2.672	<.001	.008	3	3
OESOPHAGUS	UGT3A1 →	+0.017	+2.857	<.001	.007	3	2
SOFT_TISSUE	PRKACG →	+0.009	+4.369	<.001	.008	3	2
BLOOD_Leukemia	BST1 →	+1.523	+1.936	<.001	.004	3	2
LARGE_INTESTINE	MRPL18 →	+0.400	+1.949	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 454 associations by consensus.

PROKR2 by ASXL1 expression — OESOPHAGUS

Explore this box plot interactively →