Across TCGA pan-cancer cohorts, ASTN2-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated ASTN2-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ASTN2-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ASTN2-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

BRCA, HNSC, and THCA are the cancer types where ASTN2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.955	0.904	<.001	79	view →
HNSC	OS	Median	All	0.424	0.303	.005	42	view →
THCA	OS	Tertile	II,III,IV	0.908	0.976	.012	33	view →
OV	DFS	Tertile	III,IV	0.424	0.345	.017	30	view →
BLCA	OS	Tertile	All	0.709	0.567	.006	28	view →
MESO	DFS	Quartile	All	0.127	0.541	<.001	27	view →
LUSC	OS	Tertile	III,IV	0.712	0.403	.002	26	view →
KICH	DFS	Tertile	II,III,IV	0.345	0.863	.003	25	view →
ACC	OS	Tertile	IV	0.332	0.763	.002	24	view →
UVM	DFS	Tertile	All	0.500	0.815	.022	18	view →
LAML	DFS	Median	All	0.472	0.661	.005	16	view →
CHOL	DFS	Tertile	All	0.119	0.570	.016	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

Exploration

Same gene, other analysis: ASTN2-AS1 tumor-vs-normal RNA expression · all ASTN2-AS1 data types