ASTN1

Across TCGA patient cohorts, ASTN1 mutation is significantly associated with the RNA expression of many other genes, with 8,651 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASTN1-associated genes across cancer lineages are ZWINT, CDCA8, and KIF23. Each is linked with ASTN1 in more than 6 cancer types. Because this analysis shows association rather than direction, both ASTN1-to-partner and partner-to-ASTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by ASTN1-low versus ASTN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTN1→partner) and Y-score (partner→ASTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.492	+1.338	<.001	<.001	3	6
LUAD	CDCA8 →	+0.538	+1.333	<.001	<.001	3	6
LUAD	KIF23 →	+0.507	+1.221	.001	.001	3	6
COAD	FRZB →	-0.733	-3.308	.007	.009	3	6
STAD	RRM2 →	+0.772	+2.923	.002	<.001	3	6
UCEC	WDR76 →	+0.688	+2.021	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,651 associations by consensus.

ZWINT by ASTN1 expression — UCEC

Explore this box plot interactively →