ASTN1

Across TCGA patient cohorts, ASTN1 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASTN1-associated genes across cancer lineages are ASNS, 4E-BP1, and ATM. Each is linked with ASTN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ASTN1-to-partner and partner-to-ASTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ASTN1-low versus ASTN1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTN1→partner) and Y-score (partner→ASTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.340	+1.378	.010	.007	3	4
UCEC	4E-BP1 →	+0.220	+1.925	.001	.004	3	4
COAD	ATM →	-0.455	-1.874	<.001	.047	3	4
LUAD	P-Cadherin →	+0.157	+1.016	.008	.035	3	3
LUAD	Caspase-8 →	-0.251	-2.169	.035	.002	3	3
UCEC	Cyclin-B1 →	+0.382	+1.584	.008	.015	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

ASNS by ASTN1 expression — LUAD

Explore this box plot interactively →