Across TCGA patient cohorts, ASTL mutation is significantly associated with the RNA expression of many other genes, with 1,145 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASTL-associated genes across cancer lineages are MIR3651, ATP6V1E1, and ZNHIT3. Each is linked with ASTL in more than 2 cancer types. Because this analysis shows association rather than direction, both ASTL-to-partner and partner-to-ASTL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTL→partner) and Y-score (partner→ASTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR3651 →	+0.312	+1.921	.003	.007	3	3
UCEC	ATP6V1E1 →	+0.467	+3.917	<.001	<.001	3	3
UCEC	ZNHIT3 →	+0.466	+2.828	.004	.001	3	2
SKCM	RNA5SP461 →	+0.097	+5.009	<.001	.001	3	2
SKCM	MPV17L2 →	+0.554	+3.478	<.001	.002	3	2
LIHC	TIPINP1 →	+0.087	+4.853	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,145 associations by consensus.

Exploration

ASTL survival (RNA) · tumor vs normal (RNA) · all ASTL data types