ASTL

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ASTL mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASTL-associated genes across cancer lineages are Chk2_pT68, Cyclin-B1, and 14-3-3_beta. Each is linked with ASTL in more than 1 cancer types. Because this analysis shows association rather than direction, both ASTL-to-partner and partner-to-ASTL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTL→partner) and Y-score (partner→ASTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECChk2_pT68 →-0.171-2.973.041.03532
UCECCyclin-B1 →+0.689+2.999.006.03532
UCEC14-3-3_beta →-0.092-1.986.042.03231
UCECMEK1 →+0.383+2.700.020.00631
UCECp21 →+0.173+2.321.046.03431
UCECS6_pS240_S244 →+0.502+2.000.006.03231
Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

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