Across TCGA cell cohorts, ASTL mutation is significantly associated with the RNA expression of many other genes, with 303 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASTL-associated genes across cancer lineages are AWAT2, MMP27, and SYCN. Each is linked with ASTL in more than 1 cancer types. Because this analysis shows association rather than direction, both ASTL-to-partner and partner-to-ASTL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASTL→partner) and Y-score (partner→ASTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AWAT2 →	+0.015	+4.705	<.001	.003	3	2
BLOOD_Leukemia	MMP27 →	+0.019	+4.969	<.001	.003	3	1
BLOOD_Leukemia	SYCN →	+0.037	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TMEM95 →	+0.028	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.061	+4.539	<.001	.007	3	1
LARGE_INTESTINE	GCAT →	+1.330	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 303 associations by consensus.

Exploration

ASTL survival (RNA) · tumor vs normal (RNA) · all ASTL data types