Across TCGA pan-cancer cohorts, ASS1P6 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ASS1P6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ASS1P6 RNA is repressed in tumor relative to normal tissue. In most cancer types ASS1P6 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and BRCA are the cancer types where ASS1P6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASS1P6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.049	<.001	9	view →
KIRP	All	III,IV	−0.116	<.001	8	view →
BRCA	All	II,III,IV	−0.010	.030	4	view →
KICH	All	All	−0.018	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ASS1P6 RNA expression & survival · all ASS1P6 data types