ASS1

Across TCGA pan-cancer cohorts, ASS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ASS1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ASS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ASS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, GBM, and CCRCC are the cancer types where ASS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.815	0.355	.001	31	view →
GBM	OS	Tertile	All	0.403	0.659	.008	10	view →
CCRCC	OS	Median	All	0.984	0.908	.039	5	view →
HNSC	DFS	Median	All	1.000	0.393	.018	4	view →
LSCC	OS	Tertile	II,III,IV	0.540	0.835	.023	3	view →
PDAC	OS	Median	IV	0.395	0.937	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ASS1–LUAD (DFS)

Open the LUAD breakdown →