ASS1

Across TCGA patient cohorts, ASS1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,540 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ASS1-associated genes across cancer lineages are SLPI, MUC4, and CEP290. Each is linked with ASS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ASS1-to-partner and partner-to-ASS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ASS1 versus SLPI in BRCA, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASS1→partner) and Y-score (partner→ASS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLPI →	+2.069	+0.700	<.001	<.001	3	4
UCEC	MUC4 →	+1.864	+0.884	<.001	.001	3	4
HNSC	CEP290 →	-0.475	-0.482	.004	.004	3	4
LSCC	ADGRF1 →	+1.333	+0.687	<.001	<.001	3	4
HNSC	NDRG2 →	+0.712	+0.543	<.001	<.001	3	4
LSCC	HDAC2 →	-0.496	-0.525	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,540 associations by consensus.

ASS1 vs SLPI — BRCA

Explore this scatter interactively →