ASS1

Across TCGA patient cohorts, ASS1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASS1-associated genes across cancer lineages are STAT3_pY705, CD49b, and 14-3-3_beta. Each is linked with ASS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASS1-to-partner and partner-to-ASS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by ASS1-low versus ASS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASS1→partner) and Y-score (partner→ASS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.370	-1.678	<.001	.023	3	2
UCEC	CD49b →	-0.265	-2.302	.015	.034	3	2
UCEC	14-3-3_beta →	-0.077	-3.295	.044	.009	3	1
UCEC	eIF4E →	+0.187	+2.087	.020	.005	3	1
UCEC	A-Raf_pS299 →	-0.147	-2.700	.001	.006	3	1
UCEC	ERK2 →	+0.180	+2.321	.014	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

STAT3_pY705 by ASS1 expression — UCEC

Explore this box plot interactively →