ASPSCR1

Across TCGA patient cohorts, ASPSCR1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASPSCR1-associated genes across cancer lineages are PCNA, Rictor_pT1135, and VHL. Each is linked with ASPSCR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASPSCR1-to-partner and partner-to-ASPSCR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ASPSCR1-low versus ASPSCR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPSCR1→partner) and Y-score (partner→ASPSCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.250	+2.321	.005	.006	3	3
UCEC	Rictor_pT1135 →	-0.107	-1.807	.011	.027	3	2
UCEC	VHL →	-1.276	-2.700	<.001	.006	3	2
UCEC	ATM →	-0.536	-2.321	.004	.006	3	2
UCEC	eEF2 →	+0.427	+3.000	.003	.001	3	1
UCEC	EGFR_pY1068 →	-0.215	-3.459	.038	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PCNA by ASPSCR1 expression — UCEC

Explore this box plot interactively →