ASPSCR1

Across TCGA cell cohorts, ASPSCR1 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ASPSCR1-associated genes across cancer lineages are OTOR, KRTAP12-3, and ZIC3. Each is linked with ASPSCR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASPSCR1-to-partner and partner-to-ASPSCR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOR grouped by ASPSCR1-low versus ASPSCR1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPSCR1→partner) and Y-score (partner→ASPSCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOR →	+0.030	+5.087	<.001	.004	3	1
BLOOD_Myeloma	KRTAP12-3 →	+0.116	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	ZIC3 →	+0.529	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OTOL1 →	+0.012	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR5P2 →	+0.021	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	FAM47A →	+0.026	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

OTOR by ASPSCR1 expression — URINARY_TRACT

Explore this box plot interactively →