ASPM

Across TCGA pan-cancer cohorts, ASPM mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ASPM data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ASPM mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ASPM expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where ASPM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	1.000	0.756	.015	13	view →
LUAD	DFS	Median	II,III,IV	0.921	1.000	.022	3	view →
HNSC	OS	Tertile	II,III,IV	0.859	0.618	.045	2	view →
CCRCC	OS	Tertile	All	1.000	0.637	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ASPM–LSCC (OS)

Open the LSCC breakdown →