ASPM

Across TCGA patient cohorts, ASPM mutation is significantly associated with the total protein of many other genes, with 100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASPM-associated genes across cancer lineages are ASNS, PCNA, and Rictor. Each is linked with ASPM in more than 5 cancer types. Because this analysis shows association rather than direction, both ASPM-to-partner and partner-to-ASPM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ASPM-low versus ASPM-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPM→partner) and Y-score (partner→ASPM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.516	+2.700	<.001	.005	3	6
COAD	PCNA →	+0.270	+1.919	<.001	.008	3	5
STAD	Rictor →	-0.898	-3.306	.019	.009	3	5
COAD	CDK1 →	+0.169	+1.593	.004	.011	3	5
COAD	Caspase-7-cleavedD198 →	+1.003	+1.824	<.001	.013	3	5
LUAD	PKC-delta_pS664 →	-0.162	-3.000	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

ASNS by ASPM expression — COAD

Explore this box plot interactively →