ASPM

Across TCGA cell cohorts, ASPM mutation is significantly associated with the RNA expression of many other genes, with 633 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASPM-associated genes across cancer lineages are C1orf105, CPT2, and NEIL2. Each is linked with ASPM in more than 2 cancer types. Because this analysis shows association rather than direction, both ASPM-to-partner and partner-to-ASPM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf105 grouped by ASPM-low versus ASPM-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPM→partner) and Y-score (partner→ASPM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C1orf105 →	+0.084	+3.000	<.001	.007	3	3
LARGE_INTESTINE	CPT2 →	+0.504	+3.321	.002	.002	3	3
STOMACH	NEIL2 →	+0.899	+3.392	<.001	.001	3	3
STOMACH	FAM180B →	+0.123	+2.491	.002	.006	3	3
URINARY_TRACT	SLC22A12 →	+0.005	+4.087	<.001	.009	3	2
SOFT_TISSUE	VAX1 →	+1.245	+2.714	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 633 associations by consensus.

C1orf105 by ASPM expression — BLOOD_Myeloma

Explore this box plot interactively →