ASPHD2

Across TCGA patient cohorts, ASPHD2 mutation is significantly associated with the RNA expression of many other genes, with 1,858 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASPHD2-associated genes across cancer lineages are DHX37, OXSM, and NEIL2. Each is linked with ASPHD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASPHD2-to-partner and partner-to-ASPHD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHX37 grouped by ASPHD2-low versus ASPHD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPHD2→partner) and Y-score (partner→ASPHD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DHX37 →	+0.531	+2.638	<.001	.005	3	2
UCEC	OXSM →	+0.358	+3.459	.002	.005	3	2
UCEC	NEIL2 →	+0.600	+2.502	.001	.002	3	2
UCEC	C12orf43 →	+0.297	+2.513	.003	.001	3	2
UCEC	LSM12 →	+0.533	+2.847	.003	.001	3	2
UCEC	BAP1 →	+0.317	+3.556	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,858 associations by consensus.

DHX37 by ASPHD2 expression — UCEC

Explore this box plot interactively →