Across TCGA patient cohorts, ASPDH mutation is significantly associated with the RNA expression of many other genes, with 2,098 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASPDH-associated genes across cancer lineages are SAP30, CDCA4, and PHF23. Each is linked with ASPDH in more than 1 cancer types. Because this analysis shows association rather than direction, both ASPDH-to-partner and partner-to-ASPDH results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASPDH→partner) and Y-score (partner→ASPDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAP30 →	+0.739	+2.721	.001	.003	3	2
UCEC	CDCA4 →	+0.586	+3.513	.004	.002	3	2
UCEC	PHF23 →	+0.485	+2.732	.003	.003	3	2
UCEC	ELAC2 →	+0.466	+3.354	.003	.005	3	2
UCEC	RASSF1 →	+0.477	+3.807	.001	<.001	3	2
UCEC	ACTB →	+0.477	+2.700	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,098 associations by consensus.

Exploration

ASPDH survival (RNA) · tumor vs normal (RNA) · all ASPDH data types