ASNS

Across TCGA patient cohorts, ASNS mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASNS-associated genes across cancer lineages are eEF2, INPP4B, and MSH6. Each is linked with ASNS in more than 1 cancer types. Because this analysis shows association rather than direction, both ASNS-to-partner and partner-to-ASNS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ASNS-low versus ASNS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASNS→partner) and Y-score (partner→ASNS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.336	+2.321	.014	.034	3	1
UCEC	INPP4B →	-0.249	-2.459	.044	.018	3	1
UCEC	MSH6 →	-0.327	-1.874	.009	.049	3	1
UCEC	P-Cadherin →	-0.112	-1.664	.043	.023	3	1
UCEC	PCNA →	+0.254	+3.459	.002	.005	3	1
UCEC	Shc_pY317 →	-0.164	-2.584	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eEF2 by ASNS expression — UCEC

Explore this box plot interactively →