ASNS

Across TCGA cell cohorts, ASNS RNA expression is significantly associated with the go_rna of many other GO terms, with 2,712 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ASNS-associated GO terms across cancer lineages are L-serine biosynthetic process, L-amino acid biosynthetic process, and L-serine metabolic process. Each is linked with ASNS in more than 17 cancer types. Because this analysis shows association rather than direction, both ASNS-to-partner and partner-to-ASNS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-serine biosynthetic process grouped by ASNS-low versus ASNS-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASNS→partner) and Y-score (partner→ASNS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	L-serine biosynthetic process →	+0.202	+1.906	.003	.001	2	18
LUNG_NSCLC_LUSC	L-amino acid biosynthetic process →	+0.167	+2.428	<.001	.001	3	16
BLOOD_Myeloma	L-serine metabolic process →	+0.181	+1.555	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Amino acid biosynthetic process →	+0.149	+2.174	.003	<.001	3	15
LUNG_NSCLC_LUAD	Serine family amino acid biosynthetic process →	+0.226	+1.785	<.001	<.001	3	15
LUNG_NSCLC_LUAD	Proteinogenic amino acid biosynthetic process →	+0.154	+1.384	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,712 associations by consensus.

L-serine biosynthetic process by ASNS expression — BONE

Explore this box plot interactively →