ASMTL

Across TCGA pan-cancer cohorts, ASMTL mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ASMTL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ASMTL mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ASMTL is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and CCRCC are the cancer types where ASMTL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASMTL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	−0.388	<.001	11	view →
LUAD	Male	III,IV	−0.267	.004	6	view →
CCRCC	Male	All	−0.235	<.001	6	view →
COAD	All	All	−0.147	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ASMTL–HNSC

Open the HNSC breakdown →