ASMTL

Across TCGA patient cohorts, ASMTL mutation is significantly associated with the RNA expression of many other genes, with 4,928 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASMTL-associated genes across cancer lineages are MIR6803, MTCO2P31, and MTCYBP36. Each is linked with ASMTL in more than 2 cancer types. Because this analysis shows association rather than direction, both ASMTL-to-partner and partner-to-ASMTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6803 grouped by ASMTL-low versus ASMTL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASMTL→partner) and Y-score (partner→ASMTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6803 →	+0.083	+3.603	<.001	<.001	3	3
CESC	MTCO2P31 →	+0.039	+5.579	<.001	.001	3	2
READ	MTCYBP36 →	+0.159	+6.257	<.001	.001	3	2
READ	RPS19P6 →	+0.228	+5.039	<.001	.008	3	2
READ	RPS29P2 →	+0.443	+6.257	<.001	.001	3	2
READ	LINC02514 →	+0.282	+5.039	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,928 associations by consensus.

MIR6803 by ASMTL expression — UCEC

Explore this box plot interactively →