ASMTL

Across TCGA cell cohorts, ASMTL mutation is significantly associated with the drug of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASMTL-associated genes across cancer lineages are QL-XII-61, Pevonedistat, and Ispinesib Mesylate. Each is linked with ASMTL in more than 1 cancer types. Because this analysis shows association rather than direction, both ASMTL-to-partner and partner-to-ASMTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, QL-XII-61 grouped by ASMTL-low versus ASMTL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASMTL→partner) and Y-score (partner→ASMTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	QL-XII-61 →	+0.393	+2.672	.027	.039	3	1
LARGE_INTESTINE	Pevonedistat →	+0.703	+2.649	.042	.046	3	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.616	+2.874	.047	.021	3	1
LARGE_INTESTINE	THR-102 →	+0.313	+2.722	.034	.040	3	1
LARGE_INTESTINE	GSK690693 →	+0.535	+2.874	.026	.021	3	1
LARGE_INTESTINE	ARRY-520 →	+0.756	+2.807	.032	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

QL-XII-61 by ASMTL expression — LARGE_INTESTINE

Explore this box plot interactively →