Across TCGA patient cohorts, ASMT mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASMT-associated genes across cancer lineages are EGFR_pY1068, Shc_pY317, and ATM. Each is linked with ASMT in more than 1 cancer types. Because this analysis shows association rather than direction, both ASMT-to-partner and partner-to-ASMT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASMT→partner) and Y-score (partner→ASMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.285	-2.700	.011	.006	3	1
UCEC	Shc_pY317 →	-0.149	-2.700	.029	.006	3	1
UCEC	ATM →	-0.449	-2.700	.028	.006	3	1
UCEC	Caspase-7-cleavedD198 →	+0.771	+3.341	.003	.005	3	1
UCEC	CD49b →	-0.252	-2.980	.049	.036	3	1
UCEC	C-Raf →	+0.132	+2.000	.041	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

ASMT survival (RNA) · tumor vs normal (RNA) · all ASMT data types