ASL

Across TCGA pan-cancer cohorts, ASL mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ASL data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ASL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ASL expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and HNSC are the cancer types where ASL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.884	.017	90	view →
PDAC	OS	Median	II,III,IV	0.968	0.698	.015	16	view →
HNSC	OS	Quartile	All	0.330	1.000	.036	6	view →
CCRCC	OS	Tertile	II,III,IV	1.000	0.813	.027	5	view →
LSCC	DFS	Median	III,IV	0.656	0.938	.028	4	view →
UCEC	DFS	Median	All	1.000	0.936	.023	2	view →
GBM	DFS	Quartile	All	0.646	0.883	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ASL–COAD (DFS)

Open the COAD breakdown →