ASH1L

Across TCGA pan-cancer cohorts, ASH1L mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ASH1L data layer compared with 28 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ASH1L mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ASH1L expression acts as an unfavorable survival marker, although some lineages such as OV and UCEC show a favorable association.

LSCC, OV, and UCEC are the cancer types where ASH1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.576	0.879	.001	10	view →
OV	DFS	Median	All	1.000	0.683	.026	4	view →
UCEC	DFS	Median	All	1.000	0.931	.021	2	view →
HNSC	OS	Median	II,III,IV	0.627	1.000	.028	2	view →
PDAC	OS	Quartile	All	1.000	0.508	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ASH1L–LSCC (DFS)

Open the LSCC breakdown →