ASH1L

Across TCGA patient cohorts, ASH1L mutation is significantly associated with the total protein of many other genes, with 85 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASH1L-associated genes across cancer lineages are Cyclin-E2, eIF4E, and Caspase-8. Each is linked with ASH1L in more than 4 cancer types. Because this analysis shows association rather than direction, both ASH1L-to-partner and partner-to-ASH1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by ASH1L-low versus ASH1L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASH1L→partner) and Y-score (partner→ASH1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.375	+2.025	<.001	.016	3	5
UCEC	eIF4E →	+0.148	+1.722	.002	<.001	3	4
UCEC	Caspase-8 →	-0.240	-1.584	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.567	+1.243	<.001	<.001	3	4
COAD	Claudin-7 →	+0.489	+3.000	.037	.034	3	4
BLCA	p90 RSK_pT359_S363 →	-0.128	-1.584	.014	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

Cyclin-E2 by ASH1L expression — COAD

Explore this box plot interactively →