ASH1L

Across TCGA cell cohorts, ASH1L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,100 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ASH1L-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Positive regulation of mRNA catabolic process, and Negative regulation of chromosome condensation. Each is linked with ASH1L in more than 17 cancer types. Because this analysis shows association rather than direction, both ASH1L-to-partner and partner-to-ASH1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by ASH1L-low versus ASH1L-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASH1L→partner) and Y-score (partner→ASH1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.073	+1.284	<.001	<.001	3	18
STOMACH	Positive regulation of mRNA catabolic process →	+0.077	+1.284	<.001	<.001	3	18
STOMACH	Negative regulation of chromosome condensation →	+0.183	+1.217	<.001	<.001	3	17
OESOPHAGUS	Positive regulation of mRNA metabolic process →	+0.068	+0.704	<.001	<.001	3	17
BREAST	Positive regulation of TORC2 signaling →	+0.120	+1.174	<.001	<.001	3	17
BONE	Negative regulation of gene expression, epigenetic →	+0.098	+0.991	.001	<.001	2	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,100 associations by consensus.

Epigenetic regulation of gene expression by ASH1L expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →