ASH1L

Across TCGA cell cohorts, ASH1L mutation is significantly associated with the RNA expression of many other genes, with 680 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASH1L-associated genes across cancer lineages are TMIGD1, GAPDHS, and ANKRD54. Each is linked with ASH1L in more than 2 cancer types. Because this analysis shows association rather than direction, both ASH1L-to-partner and partner-to-ASH1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMIGD1 grouped by ASH1L-low versus ASH1L-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASH1L→partner) and Y-score (partner→ASH1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TMIGD1 →	+0.023	+4.169	.003	.008	3	3
URINARY_TRACT	GAPDHS →	+0.028	+3.736	.005	.002	3	2
LARGE_INTESTINE	ANKRD54 →	+0.455	+3.526	.001	<.001	3	2
LARGE_INTESTINE	PHF5A →	+0.516	+3.043	<.001	<.001	3	2
LARGE_INTESTINE	ZC3H14 →	+0.434	+3.169	.003	.006	3	2
LARGE_INTESTINE	OIP5 →	+0.626	+2.364	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 680 associations by consensus.

TMIGD1 by ASH1L expression — CNS

Explore this box plot interactively →