ASGR2

Across TCGA patient cohorts, ASGR2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,378 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ASGR2-associated genes across cancer lineages are IGF1, LCT-AS1, and RNU4-71P. Each is linked with ASGR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASGR2-to-partner and partner-to-ASGR2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ASGR2 versus IGF1 in BRCA, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASGR2→partner) and Y-score (partner→ASGR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGF1 →	+0.990	+0.700	.002	<.001	3	2
LUAD	LCT-AS1 →	-0.122	-0.336	.007	.005	3	2
GBM	RNU4-71P →	+0.766	+0.849	<.001	.006	3	2
LSCC	CLDN8 →	-1.905	-0.523	<.001	<.001	3	2
BRCA	STMN1 →	-0.919	-0.596	.007	.004	3	2
BRCA	APLNR →	+0.668	+0.456	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,378 associations by consensus.

ASGR2 vs IGF1 — BRCA

Explore this scatter interactively →