ASGR2

Across TCGA patient cohorts, ASGR2 mutation is significantly associated with the RNA expression of many other genes, with 1,119 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASGR2-associated genes across cancer lineages are HMGN1P34, OR5P1P, and FXNP2. Each is linked with ASGR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASGR2-to-partner and partner-to-ASGR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGN1P34 grouped by ASGR2-low versus ASGR2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASGR2→partner) and Y-score (partner→ASGR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	HMGN1P34 →	+0.221	+5.018	<.001	.004	3	3
UCEC	OR5P1P →	+0.049	+2.602	<.001	.006	3	2
UCEC	FXNP2 →	+0.263	+2.191	<.001	.002	3	2
SKCM	PPP1R1AP1 →	+0.115	+2.562	<.001	.006	3	2
UCEC	LONP1 →	+0.646	+2.818	<.001	.001	3	2
UCEC	RNU6-839P →	+0.187	+5.258	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,119 associations by consensus.

HMGN1P34 by ASGR2 expression — BLCA

Explore this box plot interactively →