ASGR2

Across TCGA patient cohorts, ASGR2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASGR2-associated genes across cancer lineages are PCNA, 14-3-3_beta, and EGFR_pY1068. Each is linked with ASGR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASGR2-to-partner and partner-to-ASGR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ASGR2-low versus ASGR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASGR2→partner) and Y-score (partner→ASGR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.193	+2.115	.041	.019	3	2
UCEC	14-3-3_beta →	-0.106	-3.143	.016	.018	3	1
UCEC	EGFR_pY1068 →	-0.269	-2.115	.014	.019	3	1
UCEC	eIF4E →	+0.187	+2.820	.042	.035	3	1
UCEC	INPP4B →	-0.392	-2.794	.005	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.170	-2.102	.020	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PCNA by ASGR2 expression — UCEC

Explore this box plot interactively →