ASGR2

Across TCGA cell cohorts, ASGR2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ASGR2-associated genes across cancer lineages are PRSS45P, GH1, and LCN1. Each is linked with ASGR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASGR2-to-partner and partner-to-ASGR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS45P grouped by ASGR2-low versus ASGR2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASGR2→partner) and Y-score (partner→ASGR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRSS45P →	+0.019	+5.415	<.001	.004	3	1
SKIN	GH1 →	+0.056	+5.415	<.001	.004	3	1
BLOOD_Leukemia	LCN1 →	+0.057	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PRSS45P by ASGR2 expression — SKIN

Explore this box plot interactively →