ASGR1

Across TCGA patient cohorts, ASGR1 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ASGR1-associated genes across cancer lineages are DEFB103A, RNA5SP419, and RNA5SP410. Each is linked with ASGR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ASGR1-to-partner and partner-to-ASGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB103A grouped by ASGR1-low versus ASGR1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASGR1→partner) and Y-score (partner→ASGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DEFB103A →	+0.059	+7.930	<.001	.008	3	3
UCEC	RNA5SP419 →	+0.990	+2.755	<.001	.009	3	2
UCEC	RNA5SP410 →	+0.951	+3.110	<.001	.002	3	2
UCEC	RNA5SP416 →	+1.025	+2.902	<.001	.006	3	2
UCEC	RNA5SP421 →	+1.174	+2.925	<.001	.003	3	2
UCEC	RNA5SP415 →	+0.972	+3.167	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

DEFB103A by ASGR1 expression — LUAD

Explore this box plot interactively →