ASGR1

Across TCGA cell cohorts, ASGR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,916 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ASGR1-associated GO terms across cancer lineages are AMPA glutamate receptor clustering, Glutamate receptor clustering, and Locomotory exploration behavior. Each is linked with ASGR1 in more than 14 cancer types. Because this analysis shows association rather than direction, both ASGR1-to-partner and partner-to-ASGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMPA glutamate receptor clustering grouped by ASGR1-low versus ASGR1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ASGR1→partner) and Y-score (partner→ASGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AMPA glutamate receptor clustering →	+1.363	+0.946	<.001	.001	3	15
OESOPHAGUS	Glutamate receptor clustering →	+1.363	+0.946	<.001	.001	3	15
OESOPHAGUS	Locomotory exploration behavior →	+0.306	+1.045	<.001	.006	3	13
URINARY_TRACT	Thigmotaxis →	+0.177	+0.849	<.001	<.001	3	11
LUNG_SCLC	Regulation of telomere maintenance via telomere lengthening →	+0.082	+1.591	<.001	<.001	3	10
BONE	DNA topological change →	+0.136	+3.366	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,916 associations by consensus.

AMPA glutamate receptor clustering by ASGR1 expression — OESOPHAGUS

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