ASGR1

Across TCGA cell cohorts, ASGR1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ASGR1-associated genes across cancer lineages are CYP27C1, OR2M5, and HSFY2. Each is linked with ASGR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ASGR1-to-partner and partner-to-ASGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP27C1 grouped by ASGR1-low versus ASGR1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ASGR1→partner) and Y-score (partner→ASGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CYP27C1 →	+0.049	+4.450	<.001	.001	3	1
LARGE_INTESTINE	OR2M5 →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	TMEM244 →	+0.688	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CYP27C1 by ASGR1 expression — BLOOD_Leukemia

Explore this box plot interactively →