ASF1B

Across TCGA pan-cancer cohorts, ASF1B mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ASF1B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where ASF1B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ASF1B is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LSCC, HNSC, and LUAD are the cancer types where ASF1B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ASF1B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+1.105	<.001	8	view →
HNSC	All	III,IV	+0.352	<.001	8	view →
LUAD	Male	All	+0.469	<.001	4	view →
PDAC	All	III,IV	−0.643	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ASF1B–LSCC

Open the LSCC breakdown →